| Rank | Player (age), + - HOFer, Bold - Active | Y/G | Years | Teams |
|---|---|---|---|---|
| 1. | Kurt Warner (37) | 259.9 | 1998-2008 | 3TM |
| 2. | Peyton Manning (32) | 257.8 | 1998-2008 | clt |
| 3. | Drew Brees (29) | 245.4 | 2001-2008 | 2TM |
| 4. | Marc Bulger (31) | 245.3 | 2002-2008 | ram |
| 5. | Jay Cutler (25) | 243.9 | 2006-2008 | den |
| 6. | Carson Palmer (29) | 240.5 | 2004-2008 | cin |
| 7. | Daunte Culpepper (31) | 239.3 | 1999-2008 | 4TM |
| 8. | Brett Favre (39) | 238.6 | 1991-2008 | 3TM |
| 9. | Trent Green (38) | 235.3 | 1997-2008 | 4TM |
| 10. | Tom Brady (31) | 234.0 | 2000-2008 | nwe |
| 11. | Donovan McNabb (32) | 218.8 | 1999-2008 | phi |
| 12. | Jon Kitna (36) | 213.2 | 1997-2008 | 3TM |
| 13. | Kerry Collins (36) | 210.1 | 1995-2008 | 5TM |
| 14. | Brian Griese (33) | 209.0 | 1998-2008 | 4TM |
| 15. | Jake Delhomme (33) | 207.9 | 1999-2008 | 2TM |
| 16. | Jeff Garcia (38) | 205.9 | 1999-2008 | 5TM |
| 17. | Philip Rivers (27) | 205.7 | 2004-2008 | sdg |
| 18. | Ben Roethlisberger (26) | 205.1 | 2004-2008 | pit |
| 19. | Chad Pennington (32) | 204.6 | 2000-2008 | 2TM |
| 20. | Jason Campbell (27) | 201.2 | 2006-2008 | was |
| 21. | Eli Manning (27) | 200.3 | 2004-2008 | nyg |
| 22. | Byron Leftwich (28) | 178.2 | 2003-2008 | 3TM |
| 23. | Brad Johnson (40) | 177.2 | 1994-2008 | 4TM |
| 24. | Rex Grossman (28) | 176.1 | 2003-2008 | chi |
| 25. | David Garrard (30) | 172.7 | 2002-2008 | jax |
| 26. | David Carr (29) | 166.4 | 2002-2008 | 3TM |
| 27. | Matt Hasselbeck (33) | 165.8 | 1999-2008 | 2TM |
| 28. | Kyle Orton (26) | 161.2 | 2005-2008 | chi |
| 29. | Tony Romo (28) | 157.6 | 2004-2008 | dal |
| 30. | Patrick Ramsey (29) | 156.1 | 2002-2008 | 3TM |
| 31. | Vince Young (25) | 150.4 | 2006-2008 | oti |
| 32. | J.P. Losman (27) | 147.9 | 2004-2008 | buf |
| 33. | Gus Frerotte (37) | 144.8 | 1994-2008 | 7TM |
| 34. | Josh McCown (29) | 137.1 | 2002-2008 | 4TM |
| 35. | Sage Rosenfels (30) | 129.9 | 2002-2008 | 2TM |
| 36. | Matt Schaub (27) | 105.3 | 2004-2008 | 2TM |
| 37. | Damon Huard (35) | 98.5 | 1998-2008 | 3TM |
| 38. | Seneca Wallace (28) | 81.3 | 2005-2008 | sea |
| 39. | Antwaan Randle El (29) | 2.5 | 2002-2008 | 2TM |
| 40. | LaDainian Tomlinson (29) | 1.1 | 2001-2008 | sdg |
| 41. | Marty Booker (32) | 0.9 | 1999-2008 | 2TM |
| Mark Bradley (26) | 0.9 | 2005-2008 | 2TM | |
| 43. | Ronnie Brown (27) | 0.8 | 2005-2008 | mia |
| Leon Washington (26) | 0.8 | 2006-2008 | nyj | |
| 45. | Aveion Cason (29) | 0.7 | 2001-2008 | 3TM |
| 46. | Randy Moss (31) | 0.6 | 1998-2008 | 3TM |
| 47. | Mark Clayton (26) | 0.5 | 2005-2008 | rav |
| Jerheme Urban (28) | 0.5 | 2004-2008 | 2TM | |
| Brad Maynard (34) | 0.5 | 1997-2008 | 2TM | |
| Clinton Portis (27) | 0.5 | 2002-2008 | 2TM |